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An Early Detection System for Highly Pathogenic H5N1 Avian ...

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An Early Detection System for Highly Pathogenic H5N1 Avian Influenza in Wild Migratory Birds U.S. Interagency Strategic PlanPage 13/14/06 1An Early Detection System for Highly Pathogenic H5N1 Avian Influenza in Wild Migratory Birds U.S. Interagency Strategic Plan Introduction Avian influenza (AI) is a type A influenza virus that is naturally found in certain species of waterfowl and shorebirds. However the occurrence of highly pathogenic avian influenza (HPAI) subtype highly pathogenic H5N1 avian influenza has raised concern regarding the potential impact on wild birds domestic poultry and human health should it be introduced into the United States (U.S.). Numerous potential routes for introduction of the virus into the U.S. exist including illegal movement of domestic or wild birds contaminated products via an infected traveler as a bioterrorism event and the migration of infected wild birds. This plan focuses primarily on the detection of a potential introduction of highly pathogenic H5N1 avian influenza virus by migratory birds. Avian influenza viruses are classified on the basis of two proteins hemagglutinin (H) and neuraminidase (N) found on the surface of the virus. Specific viral subtypes have one of 16 different H proteins and one of 9 different N proteins resulting in 144 possible combinations or subtypes based on this classification scheme. Within each subtype there are numerous combinations of genetic sequences that determine the pathogenicity of the subtype to an infected host. Wild birds in particular certain species of waterfowl and shorebirds are considered to be the natural reservoirs for all 144 subtypes. These subtypes are adapted to survive in these wild species and usually cause little or no disease. However gradual genetic drift (i.e. mutation) can occur and a particular subtype can become adapted to infect other species of wild birds and domestic birds. Although this slight genetic change in the virus allows it to infect new speci ...

Source: www.doi.gov


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