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How to draw kinetic barrier diagrams for enzymecatalysed reactions J.

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How to draw kinetic barrier diagrams for enzymecatalysed. reactions. Janos SUDI. Abteilung Toxikologie ..... draw. a. kinetic barrier. diagram ...

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How to draw kinetic barrier diagrams for enzymecatalysed reactions J.Page 1Biochem.J. (1991) 276 265268(Printedin GreatBritain)How to draw kinetic barrier diagrams for enzymecatalysedreactionsJanos SUDIAbteilung ToxikologieChristianAlbrechtsUniversitatD 2300KielFederal Republic of GermanyA modified way to construct kinetic barrier diagrams is presented. Although the diagram superficially resembles a freeenergyprofileit is independent ofany conception derived from transitionstate theory. Some simple calculations referringto the lactate dehydrogenase turnover reaction at equilibrium demonstrate selfconsistency of the diagram and its directrelevance to the results of numerical simulations of the detailed course of enzymecatalysed reactions.As recently stated by Burbaumetal.1]thereareseveralproblemsin theillustration of enzymecatalysed reactions.Tocopewith theseproblems Burbaumetal. 1] have recommendedthedrawingof'kinetic barrier diagrams' insteadof theclassicalfreeenergy profiles. Someyears agoIpresentedacompletesetoften rate constantsfor describing the lactate dehydrogenase(LDH) reactionintermsofafivestepturnovermechanis m 24].This kineticsystem(Table la) allowsanumerical testing of thekinetic barrier formalism which hasnot yetbeen reported. Onthe basis ofthisnumericaltestIconclude thatverymuchcanbegained by basically altering thewayinwhichoneplots kineticbarrierdiagrams.The procedure suggested is basedonplottingina'peakandvalley'typebarri erdiagram reciprocal fluxesasmaxima andreciprocal concentrationsasminima.Accordinglytwonewco nstructional features characterize thesuggestedtypeof kineticbarrierdiagrams: (i)the minimanolongerinvolve directreferencetofree substrates andproducts;eachdiagramreferstoaspecificco mbination ofreactantconcentrations;and(ii)theconserv ationequationof classicalenzymekinetics is involved inthe calculation of both minima and maxima.The mainargumentforintroducingthe modifieddiagramis itsdirect relevancetothe results of numerical simulations of thede ...

Source: www.biochemj.org

 

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